Endothelin-1 antagonist blocks $alpha;1(I) collagen MRNA in human lung fibroblasts
نویسندگان
چکیده
منابع مشابه
Type I and type III collagen mRNA expression in human lung fibroblasts.
The predominant histological features of pulmonary fibrosis are an accumulation of collagen in the alveolar interstitium. and an increase in the number of fibroblasts [ l ] . There is an alteration in collagen production with an increase in Type I collagen relative to Type II. The mechanisms involved in this regulation of collagen production at transcriptional and translational level are poorly...
متن کاملβ₂-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts.
Human lung fibroblasts are a potential source of endothelin-1 (ET-1), a pro-fibrotic mediator. The present study explored possible muscarinic and β-adrenergic modulations of ET-1 expression in human lung fibroblasts. MRC-5 human lung fibroblasts were cultured. Expression of prepro-endothelin-1 (ppET-1) mRNA was determined by quantitative real time PCR. [(3)H]-Proline incorporation was determine...
متن کاملEndothelin ETA Receptor Antagonist Blocks Cardiac Hypertrophy Provoked
Background We have recently shown that angiotensin IIinduced hypertrophy of cultured rat cardiomyocytes was partially blocked by an endothelin (ET) receptor antagonist (BQ123) selective for the ETA subtype, suggesting the possible involvement of endogenous ET-1 in the mechanism of cardiac hypertrophy in vitro. In the present study, we studied the in vivo blockade effects of BQ123 on cardiac hyp...
متن کاملIonizing Radiation Induces Cytokines, MMP-1, TIMP-1 and Supresses Type I Collagen mRNA Expressions in Human Gingival Fibroblasts
We aimed to evaluate the effects of ionizing radiation on the proliferation of gingival fibroblasts and the expressions of proinflammatory cytokines and matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and type I collagen (type I Col) mRNA transcripts. Gingival fibroblasts were treated with radiation doses as follows; 0.5 Gy, 1 Gy, 2 Gy, 4 Gy, 6 Gy, an...
متن کاملEndothelin-1 expression in vascular adventitial fibroblasts.
Endothelial cells are a major source of endothelin (ET)-1, but the possibility that vascular adventitial fibroblasts generate ET-1 has not been explored. We hypothesized that aortic adventitial fibroblasts have the ability to produce ET-1, which may contribute to extracellular matrix synthesis. Vascular adventitial fibroblasts were isolated from mouse aorta and incubated with various concentrat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2002
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(02)02635-3